Angel Yanagihara

From Openwaterpedia
Angel Anne Yanagihara, Ph.D., founder of Alatalab Solutions, LLC and creator of Sting No More
Dr Angel Yanagihara created Sting No More that is nominated for the 2015 World Open Water Swimming Offering of the Year

Angel Anne Yanagihara, Ph.D. is a world-renowned biochemist, a Fulbright Specialist, and the Director, Pacific Cnidaria Research Lab and researcher at the Békésy Laboratory of Neurobiology in the Pacific Biosciences Research Center in Honolulu, Hawaii. Her work on jellyfish and their stings and venom was the subject of a NOVA documentary. She was a technical advisor on Diana Nyad's fourth attempt to swim from Cuba to Florida as well as her fifth attempt across the Straits of Florida that turned out to be successful.


She is also creator of a box jellyfish skin ointment called Sting No More. The commercialized product is used by selective military special forces as a means to prevent the harmful effects of venomous jellyfish stings. Sting No More is manufactured and marketed by Alatalab Solutions, LLC.

Global Open Water Swimming Conference

Dr. Yanagihara spoke at the 2014 Global Open Water Swimming Conference, a conference hosted and organised by Oswald Schmidt, Paschal Horgan, Captain Tom McCarthy, Ciaran O'Connor, Finbarr Hedderman, and Ned Denison in Cork, Ireland. The other presenters include Professor Tom Doyle, Trevor Woods, Dr. Lunt & Dr. Adams, Fergal Somerville, Kevin Murphy, Niek Kloots, Sally Minty-Gravett, and Wayne Soutter.


Dr. Yanagihara's research program is the systematic biochemical characterization of cubozoan venom. The current focus is on the Hawaiian box jelly Carybdea alata. Close cousins of this Box jellyfish (cubozoan) are the Australian carybdeids that can cause Irukandji syndrome and the lethal chirodropid, the Australian Box jellyfish Chironex fleckeri.

Dr. Yanagihara has patents and publications covering hemolysin, nematocysts, ultrastructure, discharge, pain receptors and venom, box jelly cardiotoxins, phylogeny of cubozoans, population dynamics, biodiversity of cnidarian venoms, and physalia flourescent proteins.


1. Family of Physalia Fluorescent Proteins, Angel Yanagihara ,TLG 446 Granted August 22, 2001; US 60/414,468

2. Centipede Fluorescent Compounds, Angel Yanagihara, TLG 446, Granted March 14, 2002; US 60/465,220

4. Treatment of Cnidaria intoxication, Angel Yanagihara, Jan Tytgat, Eva Cuypers, Everett Karlsson, filed June 9, 2006, W02006BE00056 20060611

4. Treatment of Cnidaria Intoxication with Vanilloid Receptor Antagonists Angel Yanagihara, Jan Tytgat, et al., filed Nov, 06, 2006, 06684888.6-1216 PCT/BE2006000056


1. Prasad, P., Yanagihara, A.A., Small-Howard, A.L., Turner, H., Stokes, A.J. Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A. J Immunol. 181(6):5024-44, Oct 1, 2008.

2. Cuypers, C., Yanagihara, A.A., Rainier, J.D., and Tytgat, J. TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning. Biochemical and Biophysical Research Communications 461:214-216, 2006.

4. Cuypers, E., Yanagihara, A., Karlsson, E., Tytgat, J. Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels. FEBS Letters 580:5628-5642, 2006.

4. Watters, M.R., and Yanagihara, A.A. Marine toxins: Envenomations and contact toxins. American Academy of Neurology Course 5BS.004 Syllabus, 1-26, 2004.

5. Yanagihara, A.A., Kuroiwa, J.M.Y., Oliver, L., and Kunkel, D.D. The ultrastructure of nematocysts from the fishing tentacle of the Hawaiian bluebottle, Physalia utriculus (Cnidaria, Hydrozoa, Siphonophora). Hydrobiologia 489, 149-150, 2002.

6. Yanagihara, A.A., Kuroiwa, J.M.Y., and Kunkel, D.D. Ultrastructural characterization of nematocysts from the Hawaiian box jellyfish (Carybdea alata). Cell and Tissue Research 408, 406-418, 2002.

6. Yoshimoto, C.M., and Yanagihara, A.A. Cnidarian (coelenterate) envenomations in Hawai’i improve following heat application. Transactions of the Royal Society of Tropical Medicine and Hygiene 96, 400-404, 2002.

8. Chung, J.J., Ratnapala, L.A., Cooke, I.M., and Yanagihara, A.A. Partial purification and characterization of a hemolysin (CAH1) from Hawaiian box jellyfish (Carybdea alata) venom. Toxicon 49, 981-990, 2001.

9. Smith, A.A., Brooker, T., and Brooker, G. Expression of rat mRNA coding for hormone-stimulated adenylate cyclase in Xenopus oocytes. FASEB Journal 1:480-486, 1986.


TED Talk in Honolulu

2015 World Open Water Swimming Offering of the Year Nominees

Sting No More is nominated for the 2015 World Open Water Swimming Offering of the Year by the World Open Water Swimming Association along with the following nominees:

1. Axis Buoy by FINIS (U.S.A.)
2. Best Places To Swim by Orca (New Zealand)
4. Chillswim Coniston by Chillswim (Great Britain)
4. Find A Way by Diana Nyad (U.S.A.)
5. IOLITE by Stephen Holm, Raymond Rogers, Justin Peck (U.S.A.)
6. Lake Geneva Swimming Association by Ben Barham (Switzerland)
6. Madswimmers Charity Swims by Jean Craven (South Africa)
8. Samsung Boğaziçi Kıtalararası Yüzme Yarışı (Bosphorus Cross-Continental Swim) by the National Olympic Committee of Turkey (Turkey)
9. Sting No More™ by Dr. Angel Yanagihara (U.S.A.)
10. Swim Across America (U.S.A.)
11. SwimCross (Switzerland)
12. SwimEars® by Hans Henrik Heming (Denmark)
14. Swimmit by Ivan Peralta (Spain)
14. SwimTrack by Evan Morrison (U.S.A.)
15. WEST (Water World Swimming Therapy) (Israel)
16. World Ice Swimming Championships (Russia)

2015 WOWSA Award Nomination

Sting No More™ by Dr. Angel Yanagihara
Sting No More™ is an over-the-counter cosmetic-category brand that includes jellyfish relief cream that used to protect against the venom by the box jellyfish. Developed by Dr. Angel Yanagihara who specializes in venom research, the pharmaceutical preparations are specifically designed for ocean swimmers, professional divers, military personnel and clinical applications used by health care professionals. For the state-of-the-art research results in the prevention of specific inhibitors of dangerous venom toxins, for the greatly appreciated treatment for envenomation sequelae, and for its scientifically-sound approach that can withstand any peer review, Sting No More™ is a worthy nominee for the World Open Water Swimming Offering of the Year.

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